Subscribe

Thiopurine Methyltransferase (TPMT) Activity and Azathioprine Therapy

Specialty:

Clinical Pharmacology & Toxicology
Emergency Medicine & Critical Care
Emergency Medicine & Critical Care
Nephrology, Urology, Obstetrics & Gynecology, Pedatrics, Genetics

Objective:

ICD-10:

Description:

Azathioprine is inactivated by thiopurine methyltransferase (TPMT). Patients with low TPMT activity are more likely to suffer adverse side effects, while patients with high TPMT activity may fail to show a clinical response to therapy. Measuring the TPMT activity in a patient can help to guide azathioprine therapy in a patient with Crohn's disease, leukemia or after transplantation.

To read more or access our algorithms and calculators, please log in or register.

RECENT TWEETS

medal descover
medal iphone