Wierda et al developed nomograms for evaluating an untreated patient with chronic lymphocytic leukemia. This can help to identify a patient who may benefit from more aggressive management or a novel therapy. The authors are from M.D. Anderson Cancer Center in Houston.
Parameters:
(1) age in years
(2) natural logarithm of serum beta-2 microglobulin in mg/L (reference range 0.6 to 2.0 mg/L)
(3) natural logarithm of serum alkaline phosphatase (reference range 38 to 126 U/L)
points for age =
= (1.333 * (age in years)) - 20
points for beta-2 microglobulin =
= (21.76 * LN (beta-2 microglobulin))
points for alkaline phosphatase =
= (21.70 * LN(serum alkaline phosphatase)) - 61
The summation of the points gives an equation that is similar to that given in the paper:
