A patient with sickle cell disease may develop a number of acute exacerbations termed crises. The number of crises that a patient experiences correlates with disease severity and prognosis.
Types of crises in sickle cell disease:
(1) marrow aplasia
(2) hemolytic anemia
(3) sequestration in
(4) thrombosis with infarction
(4a) bone pain (localized or generalized)
(4d) neurological (stroke, etc)
A crisis may be mixed, including two or more types.
A crisis needs to be distinguished from
(1) complications such as cholelithiasis.
(2) concurrent disease like appendicitis or osteomyelitis.
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Specialty: Hematology Oncology, Clinical Laboratory, Genetics