Cooperberg et al described the Cancer of the Prostate Risk Assessment (CAPRA) scoring system. This can help predict prostate cancer recurrence following radical prostatectomy. The authors are from the University of California in San Francisco.
Selection:
(1) prostate cancer with T stage T1, T2 or T3a
(2) 6 or more prostate needle cores
Parameters:
(1) age of the patient in years
(2) preoperative serum PSA in ng/mL
(3) first and second Gleason grades on the needle biopsy
(4) clinical T stage
(5) percent positive biopsy cores
|
Parameter |
Finding |
Points |
|
age |
< 50 years |
0 |
|
|
>= 50 years |
1 |
|
serum PSA |
<= 6 ng/mL |
0 |
|
|
6.1 - 10 ng/mL |
1 |
|
|
10.1 - 20 ng/mL |
2 |
|
|
20.1 - 30 ng/mL |
3 |
|
|
> 30 ng/mL |
4 |
|
Gleason grade |
first 1 to 3; second 1 to 3 |
0 |
|
|
first 1 to 3; second 4 or 5 |
1 |
|
|
first 4 or 5 |
3 |
|
clinical T stage |
T1 or T2 |
0 |
|
|
T3a |
1 |
|
percent positive biopsy cores |
< 34% |
0 |
|
|
>= 34% |
1 |
total score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 10
• The higher the score the greater the risk for recurrence after radical prostatectomy.
|
CAPRA Score |
5 Year Recurrence Free Survival (SEARCH) |
|
0 or 1 |
86% |
|
2 |
75% |
|
3 |
65% |
|
4 |
60% |
|
5 |
52% |
|
6 |
29% |
|
7 to 10 |
20% |
SEARCH = Shared Equal Access Regional Cancer Hospital database
Specialty: Hematology Oncology, Surgery, general, Urology
