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The Sheiner-Tozer Equation for Normalizing the Total Serum Phenytoin Concentration in a Patient with Hypoalbuminemia

Specialty:

Clinical Pharmacology & Toxicology
Emergency Medicine & Critical Care
Emergency Medicine & Critical Care
Neurology, Psychiatry, Ophthalmology & Otolaryngology

Objective:

ICD-10:

Description:

Normally over 90% of phenytoin in the serum is bound to albumin. Schiner and Tozer proposed an equation for normalizing a total serum phenytoin measurement in a patient with hypoalbuminemia. The calculated value is the estimated total serum phenytoin concentration that would be expected if the serum albumin was normal.

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