Stevens et al developed a semi-automated method for histologic grading of invasive lobular carcinomas (ILC). The authors are from the University of Kansas.
Parameters:
(1) nuclear grade (N)
(2) Ki-67 staining proliferation index (P)
|
Parameter |
Finding |
Points |
|
nuclear grade |
small nuclei that are regular and uniform with little variation |
1 |
|
|
nuclei of moderate size and variation |
2 |
|
|
nuclei showing marked nuclear variability in size and shape |
3 |
|
Ki-67 (MIB-1) staining |
<= 9% |
1 |
|
|
10 to 25% |
2 |
|
|
> 25% |
3 |
|
Nuclear Grade |
Ki-67 Staining |
Grade |
|
1 or 2 |
1 or 2 |
1 |
|
1 or 2 |
3 |
2 |
|
3 |
1 or 2 |
2 |
|
3 |
3 |
3 |
The N+P grade correlates with the patient's overall survival.
Specialty: Hematology Oncology, Surgery, general, Obstetrics & Gynecology
ICD-10: ,
