Claus et al calculated the cumulative risk for a woman developing breast cancer by a certain age if she has a family history of breast cancer. The following tables apply if the patient has 1 or 2 second degree relatives with breast cancer. The study is based on the data from the Cancer and Steroid Hormone Study conducted by the Centers for Disease Control.
1 Second Degree Relative (Table 3, page 645)
|
|
Age of Onset in Second Degree Relative |
|
Patient |
20-29 |
30-39 |
40-49 |
50-59 |
60-69 |
70-79 |
|
29 |
0.004 |
0.003 |
0.002 |
0.001 |
0.001 |
0.001 |
|
39 |
0.014 |
0.010 |
0.007 |
0.006 |
0.005 |
0.004 |
|
49 |
0.035 |
0.027 |
0.021 |
0.017 |
0.017 |
0.013 |
|
59 |
0.070 |
0.056 |
0.045 |
0.038 |
0.038 |
0.032 |
|
69 |
0.110 |
0.090 |
0.076 |
0.067 |
0.067 |
0.058 |
|
79 |
0.142 |
0.120 |
0.104 |
0.094 |
0.094 |
0.083 |
1 Maternal and 1 Paternal Second Degree Relatives (Table 7, page 649)
Age of Relative with Earlier Age at Diagnosis: 20-29
|
|
Age of Onset in Other Second Degree Relative |
|
Patient |
20-29 |
30-39 |
40-49 |
50-59 |
60-69 |
70-79 |
|
29 |
0.007 |
0.006 |
0.005 |
0.004 |
0.004 |
0.004 |
|
39 |
0.023 |
0.020 |
0.017 |
0.016 |
0.015 |
0.014 |
|
49 |
0.057 |
0.050 |
0.044 |
0.040 |
0.038 |
0.037 |
|
59 |
0.108 |
0.095 |
0.085 |
0.079 |
0.075 |
0.073 |
|
69 |
0.160 |
0.143 |
0.130 |
0.121 |
0.116 |
0.113 |
|
79 |
0.199 |
0.179 |
0.164 |
0.155 |
0.149 |
0.145 |
Age of Relative with Earlier Age at Diagnosis: 30-39
|
|
Age of Onset in Other Second Degree Relative |
|
Patient |
30-39 |
40-49 |
50-59 |
60-69 |
70-79 |
|
29 |
0.005 |
0.004 |
0.003 |
0.003 |
0.003 |
|
39 |
0.016 |
0.014 |
0.012 |
0.011 |
0.010 |
|
49 |
0.042 |
0.036 |
0.032 |
0.030 |
0.029 |
|
59 |
0.081 |
0.071 |
0.065 |
0.061 |
0.058 |
|
69 |
0.124 |
0.111 |
0.102 |
0.097 |
InfoSpecialty: Hematology Oncology, Surgery, general, Obstetrics & Gynecology |
