The Model of Claus et al for Predicting Cumulative Probability of Breast Cancer: Relatives with Ovarian Cancer

Description

Claus et al calculated the cumulative probability of a woman developing breast cancer if she has first degree relatives with ovarian cancer. The data for the calculations is from the Cancer and Steroid Hormone Study conducted by the Centers for Disease Control and Prevention.

Cumulative Probability of Breast Cancer in a Woman with First Degree Relatives Affected by Ovarian Cancer

woman's age	1 relative with Ovarian Cancer	2 relatives with Ovarian Cancer
29	0.002	0.011
39	0.010	0.037
49	0.026	0.090
59	0.054	0.164
69	0.088	0.236
79	0.117	0.285
89	0.135	0.308

(Table 1, page 118)

Cumulative Probability of Breast Cancer in a Woman with a First Degree Relative with Ovarian and First Degree Relative with Breast Cancers

	Age of Breast Cancer Onset in First Degree Relative
woman's age	20-29	30-39	40-49	50-59	60-69	70-79	80-89
29	0.017	0.015	0.013	0.010	0.007	0.005	0.004
39	0.057	0.05	0.042	0.034	0.025	0.019	0.014
49	0.136	0.122	0.103	0.082	0.063	0.048	0.036
59	0.244	0.219	0.186	0.151	0.118	0.091	0.072
69	0.343	0.309	0.266	0.218	0.174	0.138	0.112
79	0.406	0.367	0.319	0.265	0.214	0.174	0.144
89	0.434	0.394	0.344	0.288	0.236	0.193	0.163

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The Model of Claus et al for Predicting Cumulative Probability of Breast Cancer: Relatives with Ovarian Cancer

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