The International Germ Cell Cancer Collaborative Group (IGCCCG) Classification of Metastatic Germ Cell Cancer

 

Seminomas

 

Good Prognosis:

(1) any primary site, AND

(2) no non-pulmonary visceral metastases, AND

(3) normal AFP

(4) any hCG

(5) any LDH

 

Intermediate Prognosis:

(1) any primary site, AND

(2) non-pulmonary visceral metastases, AND

(3) normal AFP

(4) any hCG

(5) any LDH

 

Poor Prognosis:

(1) no patients classified as poor prognosis

 

Prognostic Group	Percent of Seminomas	5 Year Progression Free Survival	5 Year Survival
good	90%	82%	86%
intermediate	10%	67%	72%
poor	0	NA	NA

 

 

Non-Seminomatous Germ Cell Tumors

 

Good Prognosis:

(1) testis or retroperitoneal primary, AND

(2) no non-pulmonary visceral metastases, AND

(3) AFP < 1,000 ng/mL, AND

(4) hCG < 5,000 IU/L (1,000 ng/mL), AND

(5) LDH < 1.5 times upper limit of normal

 

Intermediate Prognosis:

(1) testis or retroperitoneal primary, AND

(2) no non-pulmonary visceral metastases, AND

(3) any of the following

(3a) AFP >= 1,000 ng/mL and <= 10,000 ng/mL, OR

(3b) hCG >= 5,000 IU/L (1,000 ng/mL) and <= 50,000 IU/L (10,000 ng/mL) OR

(3c) LDH >= 1.5 and <= 10 times the upper limit of normal

 

Poor Prognosis:

(1) mediastinal primary, OR

(2) non-pulmonary visceral metastases, OR

(3) AFP > 10,000 ng/mL, OR

(4) hCG > 50,000 IU/L (10,000 ng/mL), OR

(5) LDH > 10 times upper limit of normal

Prognostic Group	Percent of Non-Seminomas	5 Year Progression Free Survival	5 Year Survival
good	56%	89%	92%
intermediate	28%	75%	80%
poor	16%	41%	48%