The computer crossmatch allows for release of blood for transfusion without requiring antiglobulin phase testing during the crossmatch.


Purported benefits:

(1) reduced technologist workload

(2) reduced exposure to biohazardous fluid

(3) reduced patient sample requirements

(4) more efficient allocation of blood inventory


Patient requirements:

(1) negative history of unexpected alloantibody

(2) negative antibody screen

(3) at least 2 separate determinations of the recipient's ABO and Rh type are made:

(3a) at least one of which is performed on a current sample

(3b) if data from an outside facility was used, the specific details must be captured in the computer system

(4) positive identification


Donor unit requirements:

(1) confirmation of ABO type from tube segment

(2) confirmation of Rh type if Rh negative from tube segment


Testing requirements:

(1) demonstration of ABO compatibility (typically an immediate spin crossmatch)

(2) check of data entry from donor and recipient testing to confirm correct


Computer system requirements:

(1) validation by the testing facility that it only releases those red blood cell products that are compatible

(1a) alerts user to discrepancies between recipient and donor types

(1b) alerts user to discrepancies between previously recorded blood types and the interpretation from current testing

(2) validation that quarantined products are not released.

(3) records the following information:

(3a) recipient demographics: patient specifics including at least 2 unique identifiers

(3b) donor: unit number, component name, ABO and Rh types

(3c) test results: recipient's ABO and Rh types, donor unit testing, antibody screen result, immediate spin crossmatch result

(3d) source of outside information if used

(3e) technologists involved


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