Vitrano et al reported the Thalassemia International Prognostic Scoring System (TIPSS). This can help to identify a patient who requires more aggressive management. The authors are from the International Working Group on Thalassemia (IWG-THAL).
Patient selection: thalassemia
Parameters:
(1) heart disease
(2) liver disease
(3) diabetes
(4) sepsis
(5) serum ALT in IU/L
(6) hemoglobin in g/dL
(7) serum ferritin in ng/mL
Parameter
Finding
Points
heart disease
no
0
yes
1.4
liver disease
no
0
yes
0.9
diabetes
no
0
yes
0.9
sepsis
no
0
yes
0.9
serum ALT
< 42 IU/L
0
>= 42 IU/L
0.6
hemoglobin
<= 9 g/dL
0.6
> 9 g/dL
0
serum ferritin
< 1,850 ng/mL
0
>= 1,850 ng/mL
0.4
value of X =
= SUM(points for all of the parameters)
TIPSS score =
= EXP(X)
Interpretation:
• minimum score: 1
• maximum scoer: 289.9
• The higher the score the greater the risk of mortality.
Score
Risk
Hazard Ratio for Death
< 2.0
low
1
2.0 to 4.99
intermediate
2.8
>= 5
high
6.4
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