A tablet needs to remain intact during shipping and handling. A friabilator is a rotating instrument that measures the friability of tablets.
The friabilator consists of a rotating plexiglas chamber with a curved baffle that allows tablets to undergo a controlled drop. A specified number of tablets are placed in the chamber which rotates at a constant speed for a specified time period.
Criteria for durability:
(1) resists breakage and crumbling
(2) resists abrasion, as measured by change in weight before and after testing
tablet weight loss in percent =
= ((tablet weight before) – (tablet weight after)) / (tablet weight before) * 100%
• Weight loss < 1% is considered adequate resistance to abrasion.
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Specialty: Pharmacology, clinical