Systemic Sclerosis-Mixed Connective Tissue Disease (SSc-MCTD) can be diagnosed if certain findings are present.
Features of Systemic Sclerosis-Mixed Connective Tissue Disease - all of the following:
(1) >= 3 of the following:
(1a) synovitis
(1b) myositis
(1c) finger swelling
(1d) Raynaud's phenomenon
(1e) acrosclerosis
(2) positive for anti-RNP antibodies (anti-U1-RNP)
(3) meet the ACR/EULAR criteria for scleroderma
where:
• Anti-RNP is antibody to extractable nuclear antigen U1-RNP complex and is the serologic hallmark of MCTD.
• Criteria 1 and 2 are the criteria for MCTD.
To read more or access our algorithms and calculators, please log in or register.
Specialty: Immunology/Rheumatology
