Description

Systemic Sclerosis-Mixed Connective Tissue Disease (SSc-MCTD) can be diagnosed if certain findings are present.


Features of Systemic Sclerosis-Mixed Connective Tissue Disease - all of the following:

(1) >= 3 of the following:

(1a) synovitis

(1b) myositis

(1c) finger swelling

(1d) Raynaud's phenomenon

(1e) acrosclerosis

(2) positive for anti-RNP antibodies (anti-U1-RNP)

(3) meet the ACR/EULAR criteria for scleroderma

 

where:

• Anti-RNP is antibody to extractable nuclear antigen U1-RNP complex and is the serologic hallmark of MCTD.

• Criteria 1 and 2 are the criteria for MCTD.


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