Some patients with systemic sclerosis may show overlap with systemic lupus erythematosus (SLE).
Epidemiologic features:
(1) younger age when diagnosed with scleroderma
(2) more often female
(3) East or South Asian
(4) longer survival vs systemic sclerosis
Cutaneous features:
(1) digital ulcers
(2) calcinosis
(3) telangiectasias
(4) Raynaud's phenomenon
(5) diffuse cutaneous or limited cutaneous scleroderma
(6) abnormal nailfold capillaries
Visceral features:
(1) pulmonary arterial hypertension
(2) interstitial lung disease (ILD)
(3) scleroderma-type renal crisis
(4) esophageal dysmotility
Laboratory features:
(1) lupus anticoagulant (SLE)
(2) anticardiolipin antibodies (SLE)
(3) Scl-70 antibody (SS)
(4) anti-centromere antibody (SS)
(5) anti-dsDNA or anti-Sm (SLE)
