Description

Some patients with systemic sclerosis may show overlap with systemic lupus erythematosus (SLE).


Epidemiologic features:

(1) younger age when diagnosed with scleroderma

(2) more often female

(3) East or South Asian

(4) longer survival vs systemic sclerosis

 

Cutaneous features:

(1) digital ulcers

(2) calcinosis

(3) telangiectasias

(4) Raynaud's phenomenon

(5) diffuse cutaneous or limited cutaneous scleroderma

(6) abnormal nailfold capillaries

 

Visceral features:

(1) pulmonary arterial hypertension

(2) interstitial lung disease (ILD)

(3) scleroderma-type renal crisis

(4) esophageal dysmotility

 

Laboratory features:

(1) lupus anticoagulant (SLE)

(2) anticardiolipin antibodies (SLE)

(3) Scl-70 antibody (SS)

(4) anti-centromere antibody (SS)

(5) anti-dsDNA or anti-Sm (SLE)


To read more or access our algorithms and calculators, please log in or register.