Acute carbon monoxide poisoning may be associated with a number of complications, which may include the capillary leak syndrome, rhabdomyolysis and a compartment syndrome.
The shift of intravascular fluids to the extravascular space plus fluid resuscitation for hypotension can result in peripheral edema and fluid collections, which increases the risk of a compartment syndrome, especially in the lower extremities.
Rhabdomyolysis due to direct carbon monoxide toxicity or compartment syndrome can occur and result in acute renal failure.
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