Sanders et al graded allergic and/or inflammatory reactions associated with transfusion therapy using a system modeled after the Common Toxicity Criteria (CTC) for adverse effects of cancer therapy. The authors are from St. Jude Children's Research Hospital, University of Tennessee and McMaster University.
Types of reactions:
(1) allergic
(2) inflammatory
(3) mixed allergic and inflammatory (features of both present)
Parameters for allergic reactions:
(1) skin changes
(2) respiratory symptom
(3) hypotension
|
Skin Changes |
Respiratory |
Hypotension |
Grade |
|
none |
none |
none |
0 |
|
transient flushing or rash |
none |
none |
1 |
|
persistent flushing or rash, urticaria |
dyspnea |
none |
2 |
|
edema or angioedema |
bronchospasm |
hypotension |
3 |
|
NA |
respiratory failure |
anaphylaxis or shock |
4 |
|
NA |
NA |
death |
5 |
Parameters for inflammatory reactions:
(1) rigors and/or chills, with/without fever
(2) discomfort
(3) hypotension
|
Rigors, Chills, Fever |
Discomfort |
Hypotension |
Grade |
|
none |
none |
none |
0 |
|
mild |
mild |
none |
1 |
|
moderate |
requires analgesics |
none |
2 |
|
severe or prolonged |
pain |
hypotension |
3 |
|
NA |
NA |
shock |
4 |
|
NA |
NA |
death |
5 |
Specialty: Clinical Laboratory
ICD-10: ,
