The first line drug for the initial intensive therapy of meliodosis is ceftazidime. Therapy should be switched to meropenem under certain circumstances.


Indications to switch to meropenem:

(1) The patient deteriorates during ceftazidime therapy.

(2) A new focus of infection develops.

(3) A repeat blood culture at 7 days of ceftazidime therapy is still positive.


Dose: 25 mg/kg, maximum dose 1 gram


Frequency: every 8 hours


Route: intravenous (IV)


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