The Swansea criteria can be used for the diagnosis of acute fatty liver of pregnancy. The original authors are from Singleton Hospital in Sketty, Swansea.
Patient selection: pregnant female
Criteria - 6 or more of the following:
(1) vomiting
(2) abdominal pain
(3) polydipsia and polyuria
(4) encephalopathy
(5) serum bilirubin > 14 µmol/L
(6) blood glucose < 4 mmol/L
(7) serum uric acid > 340 µmol/L
(8) WBC count > 11 * 10^9/L
(9) ascites or bright liver on ultrasonography
(10) serum AST or ALT > 42 IU/L
(11) serum ammonia > 47 µmol/L
(12) serum creatinine > 150 µmol/L
(13) prothrombin time > 14 seconds or aPTT > 34 seconds
(14) microvesicular steatosis on liver biopsy
The diagnosis also requires the absence of another explanation for the above finding.
