Epidermodysplasia Verruciformis (EV) is a rare inherited skin condition with a susceptibility to certain strains of human papillomavirus (HPV). These skin verrucae are at increased risk for progressing to a carcinoma.

HPV types associated with EV: 5, 8, 14d plus 10 others


Typical skin lesions: flat reddish-brown macules and pinkish-red plane papules


Locations for skin lesions: face, neck, torso


Cancers tend to develop in sun-exposed skin as the person gets older.


Types of cancer:

(1) Bowen's disease (squamous cell carcinoma in situ)

(2) squamous cell carcinoma

(3) sebaceous cell carcinoma

(4) Merkel cell carcinoma


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