Description

Prince et al developed a model for evaluating patients with primary biliary cirrhosis (PBC). This can help to identify a patient who may benefit from more aggressive management. The authors are from the Medical School at Newcastle-upon-Tyne and the University of Lancaster in England.


Patient selection: primary billiary cirrhosis

 

Parameters:

(1) age at diagnosis

(2) serum total bilirubin in mg/dL

(3) upper limit of the normal reference range for total serum bilirubin in mg/dL

(4) serum alkaline phosphatase in IU/L

(5) upper limit of the normal reference range for serum alkaline phosphatase in IU/L

(6) serum albumin in g/L

(7) lower limit of normal for serum albumin in g/L

 

ratio serum total bilirubin to ULN =

= (serum bilirubin) / (ULN for bilirubin)

 

ratio serum alkaline phosphatase to ULN =

= (serum alkaline phosphatase) / (ULN for serum alkaline phosphatase)

 

ratio of serum albumin to LLN =

= (serum albumin) / (LLN for serum albumin)

 

X =

= (0.0742 * (age in years)) + (0.195 * LN(bilirubin ratio)) + (0.261 * LN(alkaline phosphatase ratio)) - (2.7878 * (albumin ratio))

 

H for survival from the time of diagnosis =

= EXP(X)


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