Prince et al developed a model for evaluating patients with primary biliary cirrhosis (PBC). This can help to identify a patient who may benefit from more aggressive management. The authors are from the Medical School at Newcastle-upon-Tyne and the University of Lancaster in England.
Patient selection: primary billiary cirrhosis
Parameters:
(1) age at diagnosis
(2) serum total bilirubin in mg/dL
(3) upper limit of the normal reference range for total serum bilirubin in mg/dL
(4) serum alkaline phosphatase in IU/L
(5) upper limit of the normal reference range for serum alkaline phosphatase in IU/L
(6) serum albumin in g/L
(7) lower limit of normal for serum albumin in g/L
ratio serum total bilirubin to ULN =
= (serum bilirubin) / (ULN for bilirubin)
ratio serum alkaline phosphatase to ULN =
= (serum alkaline phosphatase) / (ULN for serum alkaline phosphatase)
ratio of serum albumin to LLN =
= (serum albumin) / (LLN for serum albumin)
X =
= (0.0742 * (age in years)) + (0.195 * LN(bilirubin ratio)) + (0.261 * LN(alkaline phosphatase ratio)) - (2.7878 * (albumin ratio))
H for survival from the time of diagnosis =
= EXP(X)
