Schmidt et al reported the SAVE (Survival After Veno-Arterial ECMO) score for predicting survival in a patient with refractory cardiogenic shock treated with extracorporeal membrane oxygenation (ECMO). The authors are from Monash University, Universite Pierre et Marie Curie, Alfred Hospital, Extracorporeal Life Support Organization, Chidlren's Hospital Boston, Harvard Medical School and Columbia College of Physicians and Surgeons.
Patient selection: refractory cardiogenic shock, age >= 18 years
Parameters:
(1) acute cardiogenic diagnosis (5 items)
(2) age in years
(3) weight in kilograms
(4) acute pre-ECMO organ failures (3 items)
(5) chronic renal failure
(6) duration of intubation prior to initiation of ECMO in hours
(7) peak inspiratory pressure in cm H2O
(8) pre-ECMO cardiac arrest
(9) diastolic blood pressure prior to ECMO in mm Hg
(10) pulse pressure prior to ECMO in mm Hg
(11) serum bicarbonate prior to ECMO in mmol/L
Parameter |
Finding |
Points |
myocarditis |
no |
0 |
|
yes |
3 |
refractory VT or VF |
no |
0 |
|
yes |
2 |
after heart or lung transplantation |
no |
0 |
|
yes |
3 |
congenital heart diseaes |
no |
0 |
|
yes |
-3 |
other diagnosis causing shock |
no |
0 |
|
yes |
0 |
age in years |
18 to 38 years |
7 |
|
39 to 52 years |
4 |
|
53 to 62 years |
3 |
|
>= 63 years |
0 |
weight in kilograms |
1 |
|
|
65 to 89 years |
2 |
|
>= 90 years |
0 |
acute liver failure |
no |
0 |
|
yes |
-3 |
acute CNS dysfunction |
no |
0 |
|
yes |
-3 |
acute renal failure |
no |
0 |
|
yes |
-3 |
chronic renal failure |
no |
0 |
|
yes |
-6 |
duration of intubation |
<= 10 hours |
0 |
|
11 to 29 hours |
-2 |
|
>= 30 hours |
-4 |
peak inspiratory pressure |
<= 20 cm H2O |
3 |
|
> 20 cm H2O |
0 |
pre-ECMO cardiac arrest |
no |
0 |
|
yes |
-2 |
diastolic blood pressure before ECMO |
>= 40 mm Hg |
3 |
|
< 40 mm Hg |
0 |
pulse pressure before ECMO |
> 20 mm Hg |
0 |
|
<= 20 mm Hg |
-2 |
bicarbonate before ECMO |
<= 15 mmol/L |
-3 |
|
> 15 mmol/L |
0 |
total score =
= SUM(points for all of the parameters) -6
Interpretation:
• minimum score: -35
• maximum score: 17
• The higher the score the better the survival.
Score |
Risk Class |
Survival |
>= 6 |
I |
75% |
1 to 5 |
II |
58% |
-4 to 0 |
III |
42% |
-9 to -5 |
IV |
30% |
<= -10 |
V |
18% |
Specialty: Critical Care