A person treated with methotrexate may develop a reactivation of a previous sunburn (recall reaction).


Clinical features:

(1) recurrence of a previous sunburn in the absence of sun exposure

(2) recent history of methotrexate therapy


Most patients have a single recall reaction, but rarely it may occur with subsequent doses of methotrexate.



(1) photosensitivity

(2) sunburn due to sun exposure

(3) erythroderma from other cause


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