Sulfonylureas are a commonly used oral hypoglycemic agents which are relatively safe to take.
(1) tolbutamide (Orinase)
(2) chlorpropamide (Diabinese)
(3) glyburide (Micronase, DiaBeta, Glynase)
(4) glipizide (Glucotrol)
Mechanism of action: increased secretion of insulin by the pancreatic islet cells
(1) hypersensitivity to sulfa drugs or other sulfonylureas
(2) history of adverse hematologic response to the sulfonylurea (cytopenia, aplastic anemia)
(1) insufficient pancreatic tissue (lack of insulin secretory capacity)
(2) glyburide if history of glyburide-induced hepatitis
(3) chlorpropamide if history of chlorpropamide-induced cholestatic jaundice
(4) history of sulfonylurea-induced porphyria
(5) history of photoxicity associated with sulfonylurea therapy
(6) history of SIADH while taking chlorpropamide or tolbutamide.
(1) Avoid alcohol if a disulfiram-like reactions occurs.
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Purpose: To identify potential problems that could occur if a diabetic patient is treated with a sulfonylurea.
Specialty: Endocrinology, Clinical Laboratory
Objective: risk factors, prevention
ICD-10: T38.3, E14.8, E14.9,