Cold-Induced Sweating Syndrome (CISS) is a rare inherited disorder with a range of clinical findings. Its appearance during infancy is referred to as Crisponi Syndrome. It may be associated with sudden death during infancy or early childhood.

Patient selection: cold-induced sweating syndrome (CISS)


Factors that may contribute to sudden death:

(1) Fever to 42°C (108°F) without infection can occur in infants and can lead to seizures or sudden death.

(2) Intolerance for high environmental temperatures.

(3) Respiratory distress secondary to laryngospasm.


If the patient survives infancy, then these problems may disappear gradually.

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