Petersen and Negash classified patients with mild cognitive impairment (MCI) into subtypes based on the pattern of clinical findings. Combining the subtype with other prognostic factors (PET scan, CSF analysis, genetic analysis, etc) may help to identify a patient who may benefit from more aggressive management. The authors are from the Mayo Clinic.
Patient selection: mild cognitive impairment as defined by Petersen in 17.19.12, with cognitive complaint(s) involving any cognitive domain
Cognitive domains that may be affected:
(1) memory
(2) language
(3) executive function
(4) visuospatial skills
Parameters:
(1) memory impairment
(2) number of non-memory cognitive domains affected
Memory Impairment
Number of Other Domains Affected
Subtype
yes
0
amnesiac MCI, single domain
yes
>= 1
amnesiac MCI, multiple domains
no
1
non-amnesiac MCI, single domain
no
>= 2
non-amnesiac MCI, multiple domains
where:
• For the non-amnesiac MCI there has to be at least one non-memory cognitive domain affected.
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