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Adult-Onset Still's Disease | Risk Factors for Relapse

Purpose: To identify risk factors associated with relapse for a patient with adult onset Still's disease based on the study of Kong et al.

Description

Kong et al identified risk factors for relapse in a patient with adult onset Still's disease (AOSD). These can help to identify a patient who may benefit from more aggressive management. The authors are from Dalian Medical University in Dalian, China.


 

Parameters:

(1) white blood cell count

(2) erythrocyte sedimentation rate (ESR)

(3) serum ferritin

(4) dose of corticosteroids as prednisone equivalents

Parameter

Finding

Points

white blood cell count

< 30,000 per µL

0

 

>= 30,000 per µL

1

ESR

<= 100 mm in the first hour

0

 

> 100 mm in the first hour

1

serum ferritin

< 1,500 ng/mL

0

 

>= 1,500 ng/mL

1

daily corticosteroid dose

< 40 mg prednisone

1

 

>= 40 mg prednisone

0

 

where:

• The timing of the laboratory testing was not stated.

• Pro-inflammatory cytokines (TNF alpha, IL1 alpha) are increased in patients with AOSD.

 

total number of risk factors for relapse =

= SUM(points for all 4 parameters)

 

Interpretation:

• minimum number of risk factors: 0

• maximum number of risk factors: 4

• The risk of relapse increases with the number of risk factors.

 


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Specialty

Objective

ICD-10