The Sticky Platelet Syndrome (SPS) is a common and hereditary cause of arterial and venous thrombosis which is easy to diagnose and to treat.
Inheritance: autosomal dominant
(1) There is often a family history, typically with one parent having the syndrome.
(2) The onset often occurs when the patient is relatively young (5 to 45 years of age).
(3) The patient does not have other identifiable risk factor for thrombosis.
(4) The patient may have recurrent thromboembolic phenomenon while on adequate dosages of oral anticoagulants.
Clinical History: variety of arterial and venous thrombotic episodes
(1) deep venous thrombosis with or without pulmonary emboli
(2) coronary artery thrombosis
(3) cerebrovascular thrombosis
(4) transient ischemic attacks
(5) retinal vascular thrombosis
(6) peripheral arterial thrombosis
(7) fetal wastage syndrome
History of Thrombosis
Hyperaggregability of Platelets
only one concentration of only one reagent
only one concentration of only one reagent, similar results present on repeat testing
firm diagnosis of SPS
two concentrations of one reagent
one concentration of both reagents
• platelet testing concentration: approximately 200,000 per µL
• concentrations of ADP: 2.34, 1.17, 0.58 µM (final concentration in cuvette)
• concentrations of epinephrine: 11, 1.1, 0.55 µM (final concentration in cuvette)
Hyperagglutinability to ADP
Hyperagglutinability to Epinephrine
• Low dose aspirin (acetylsalicylic acid, at 81 mg per day) is usually effective.
• If platelet aggregation does not normalize on low dose aspirin, higher doses (up to 325 mg/d) may be tried; if this fails to normalize the platelet aggregation, ticlopidine may be tried.
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Specialty: Hematology Oncology, Clinical Laboratory