Lee et al developed a staging system for M0 oral cancer. This performed better than the AJCC TNM for identifying high risk patients who may benefit from more aggressive management. The authors are from Chi-Mei Medical Center in Taiwan.
Patient selection: oral cancer, pN0 to pN2, M0
Outcomes: disease-specific survival (DSS)
Parameters:
(1) neutrophil to lymphocyte ratio
(2) perineural invasion
(3) pT stage
(4) pN stage
neutrophil to lymphocyte ratio =
= (neutrophil count) / (lymphocyte count)
Parameter
Finding
Points
neutrophil to lymphocyte ratio
<= 2.37
0
> 2.37
1
perineural invasion
absent
0
present
1
pT stage
pT1 or pT2
0
pT3 or pT4
1
pN stage
pN0 or pN1
0
pN2
3
total score =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score: 0
• maximum score: 6
Score
Stage
5-Year DSS
0
I
84%
1
II
73%
2 or 3
III
56%
4 to 6
IV
20%
Performance:
• The area under the ROC curve for 5-year DSS was 0.73.
To read more or access our algorithms and calculators, please log in or register.
