Justice et al developed a staging system for patients with AIDS based on the physiologic defects manifested. The patient's stage correlated with survival over the following year.
Patients: HIV-positive patients with clinical AIDS
|
Parameter |
Finding |
Points |
|
nutritional |
albumin < 2.0 g/dL and/or constant diarrhea |
1 |
|
respiratory |
PaO2 <= 50 mm Hg |
1 |
|
neurologic |
any neurologic manifestation |
1 |
|
hematologic |
WBC count < 2,500 per µL |
1 |
|
|
lymphocyte count < 150 per µL |
1 |
|
|
platelet count < 140,000 per µL |
1 |
|
|
hematocrit < 30% |
1 |
point score for physiologic deficits =
= SUM(physiologic deficits present)
Interpretation:
• minimum score: 0
• maximum score: 7
|
Score |
Stage |
Survival at 1 Year (in 1989) |
|
0 |
I |
50% |
|
1 |
II |
30% |
|
2 or 3 |
III |
8% |
|
4 or greater |
III |
0% |
Limitations:
• With improved therapies the prognosis has improved since 1989, but the presence of these findings still indicate severe disease.
Specialty: Infectious Diseases
ICD-10: ,
