Zinc protoporphyrin (ZPP) can help classify the degree of iron deficiency in a patient.
depleted iron stores
iron deficiency anemia
after Table 5, page 772, Hastka et al
Advantages of zinc protoporphyrin: not affected by acute phase reaction like ferritin. Increases in severe chronic inflammation reflect anemia of chronic disease.
Disadvantages of zinc protoporphyrin: may be elevated in other causes of iron-deficient erythopoiesis such as beta-thalassemia, sideroblastic anemia, anemia of chronic disease and lead poisoning
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Specialty: Hematology Oncology, Clinical Laboratory, Obstetrics & Gynecology, Pedatrics, Surgery, general, Gastroenterology