Burkitt's lymphoma can be clinically staged using a scheme developed by Murphy and Hustu, which was later modified by Magrath et al. This is helpful in determining the optimum therapy for the patient.
Clinical Findings
Stage
single extranodal tumor NOT mediastinum or abdomen
I
single nodal anatomic area NOT mediastinum or abdomen
I
single extranodal tumor with regional lymph node involvement
II
>= 2 nodal areas on same side of diaphragm
II
2 single extranodal tumors with or without regional lymph node involvement on the same side of the diaphragm
II
primary GI tumor with or without involvement of associated mesenteric nodes only
II
completely resected abdominal disease
IIR
2 single extranodal tumors on opposite sides of the diaphragm
III
>= 2 nodal areas above and below the diaphragm
III
all primary intrathoracic tumors (mediastinum, pleural, thymic)
III
all paraspinal or epidural tumors
III
all extensive primary intra-abdominal disease
III
localized but not resectable intra-abdominal disease
IIIA
widespread multiorgan abdominal disease
IIIB
any of the above with CNS and/or bone marrow involvement
IV
where:
• Primary GI tumor typically involves the ileocecal region.
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