Description

One cost saving strategy employed by some health maintenance organizations (HMOs) is to have the patient split pills or tablets into smaller dosage portions. While attractive in some circumstances, this can result in a number of problems that may outweigh the benefits.


 

Problems:

(1) variation in dosage (either too high or too low)

(2) wastage (lost or crushed product)

(3) difficulty for a disabled patient

 

Parameter

Splitting is a Good Idea

Splitting is a Bad Idea

drug toxicity

low

high

dose-response efficacy curve

flat

steep

patient eyesight

excellent

poor

patient dexterity

good

poor

patient's ability to comply with instructions

good

poor

implement requirement

no or simple tool

requires special tool (complexity)

product consistency

relatively soft

relatively hard, requiring force to split

product size

relatively large

tiny

product surface stability

flat and stable

round and unstable

ease to determine center (based on product shape)

simple (regular)

difficult (irregular)

response to splitting

intact, equally sized pieces

crumbles or very irregular pieces

 

where:

• A scored tablet may not split evenly, so that scoring is not a predictor of proper splitting.

• Some pills split better by hand while others split better using a razor.

 


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