Saposnik et al reported the SPAN-100 to quickly identify a patient who may have a suboptimal response to thrombolytic therapy. The authors are from multiple institutions in Canada and the United States.
Patient selection: acute stroke, being evaluated for intravenous infusion of tissue plasminogen activator (tPA)
Parameters:
(1) age in years
(2) NIHSS
SPAN-100 =
= (age) + (NIHSS)
If the SPAN-100 is >= 100 then positive, else negative.
Interpretation:
• A patient with a positive SPAN-100 tends to have a greater rate of intracerebral hemorrhage (ICH) after infusion of tissue plasminogen activator and a less favorable composite outcome at 3 months than patients with a negative SPAN-100.
After tPA
SPAN-100 Negative
SPAN-100 Positive
ICH
12%
42%
favorable outcome
55%
6%
Figure 1
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