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Sorafenib Advanced HCC Prognosis (SAP) Score of Edeline et al for a Patient with Advanced Hepatocellular Carcinoma

Description

Edeline et al reported the Sorafenib Advanced HCC Prognosis (SAP) score for evaluating a patient with advanced hepatocellular carcinoma. This can aid in planning therapeutic interventions. The authors are from multiple institutions in France and England.


Patient selection: advanced hepatocellular carcinoma, potential candidate for sorafenib

 

Parameters:

(1) ECOG performance status (PS)

(2) serum alpha-fetoprotein in ng/mL

(3) tumor diameter in cm

(4) serum total bilirubin in µmol/L

(5) serum albumin g/L

 

Parameter

Finding

Points

performance status

ECOG 0

0

 

ECOG 1 to 4

1

alpha-fetoprotein

<= 400 ng/mL

0

 

> 400 ng/mL

1

tumor diameter

<= 7 cm

0

 

> 7 cm

1

serum total bilirubin

<= 17 µmol/L

0

 

> 17 µmol/L

1

serum albumin

>= 36 g/L

0

 

< 36 g/L

1

 

total score =

= SUM(points for all 5 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 5

• The higher the score the worse the overall survival.

 

Score

Group

Median Overall Survival

0 or 1

A

14.9 months

2 or 3

B

7.2 months

4 or 5

C

2.5 months

 

Performance:

• The area under the ROC curve is 0.7 (6 months), 0.68 (12 months) and 0.73 (24 months).


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