Soluble P-selectin is a cell adhesion molecule found in alpha granules of platelets and Weibel-Palade bodies of endothelial cells. Receptors for soluble P-selectin include P-selectin glycoprotein ligand-1 (PSGL-1) and CD24.
Patient selection: cancer, at time of diagnosis
Parameters:
(1) soluble P-selectin
(2) surgery
(3) radiotherapy
|
Parameter
|
Finding
|
Points
|
|
soluble P-selectin
|
<53.1 ng/mL (< 75
th
percentile)
|
0
|
|
|
>= 53.1 ng/mL (>= 75
th
percentile)
|
1
|
|
surgery
|
no
|
0
|
|
|
yes
|
1
|
|
radiotherapy
|
no
|
0
|
|
|
yes
|
1
|
where:
• The points are based on hazard ratio from multivariate analylsis, which ranged from 2.6 to 3.9, with p values <= 0.003.
• The upper quartile of the normal range is indicated by the 75
th
percentile. This would be approximately the mean plus 0.68 SD.(i.e, "high normal" or above normal).
total number of risk factors =
= SUM(points for all 3 factors)
Interpretation:
• minimum number of risk factors: 0
• maximum number of risk factors: 3
• The risk of venous thromboembolism increases with the number of risk factors.
• The risk of venous thromboembolism with a soluble P-selectin >= 75
th
percentile alone was 12% vs 4% if not.
