Adamichou et al reported the SLE Risk Probability Index (SLERPI) for identifying a patient with systemic lupus erythematosus (SLE). The authors are from multiple institutions in Greece and Italy.
Parameters:
(1) malar or maculopapular rash (as defined by Aringer et al)
(2) subacute cutaneous lupus erythematosus or discoid lupus erythematosus
(3) alopecia
(4) mucosal ulcers
(5) arthritis
(6) serositis
(7) leukopenia (WBC count < 4,000 per µL at least once)
(8) thrombocytopenia (TCP) or autoimmune hemolytic anemia
(9) neurologic disorder (as defined by Petri et al)
(10) proteinuria (> 500 mg per day)
(11) ANA positive
(12) low serum C3 and C4 concentrations
(13) autoantibodies (any of anti-DNA, anti-Sm, anti-phospholipid)
(14) interstitial lung disease on high-resolution lung CT
|
Parameter
|
Finding
|
Points
|
|
malar or MP rash
|
absent
|
0
|
|
|
present
|
3
|
|
cutaneous lupus
|
absent
|
0
|
|
|
present
|
2
|
|
alopecia
|
absent
|
0
|
|
|
present
|
1.5
|
|
mucosal ulcers
|
absent
|
0
|
|
|
present
|
1
|
|
arthritis
|
absent
|
0
|
|
|
present
|
2
|
|
serositis
|
absent
|
0
|
|
|
present
|
1.5
|
|
leukopenia
|
absent
|
0
|
|
|
present
|
1.5
|
|
TCP or hemolytic anemia
|
absent
|
0
|
|
|
present
|
4.5
|
|
neurological disorder
|
absent
|
0
|
|
|
present
|
1.5
|
|
proteinuria
|
absent
|
0
|
|
|
present
|
4.5
|
|
ANA positive
|
absent
|
0
|
|
|
present
|
3
|
|
low C3 and C4
|
absent
|
0
|
|
|
present
|
2
|
|
autoantibodies
|
absent
|
0
|
|
|
present
|
2.5
|
|
interstitial lung disease
|
absent
|
0
|
|
|
present
|
-1
|
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: -1
• maximum score: 30.5
•A score > 7 indicates the presence of SLE.
Performance:
• The accuracy is reported at 94%.
• The area under the ROC curve is 0.98.
