Charrow et al studies skin lesions in patients with IgG4-related disease. The authors are from Harvard University and the University of Pennsylvania.
Skin manifestions associated with IgG4-related disease include:
(1) papules, plaques and nodules of the head and neck.
(2) pruritis
Macules and bullae were not identified in subjects.
A biopsy of a skin lesion may show fibrosis and a lymphoplasmacytic infiltrate, but the absence of these does not exclude the diagnosis.
Most patients had evidence of systemic disease. Patients with IgG4-related skin lesions may have involvement of the head and neck such as:
(1) parotid gland swelling or parotitis
(2) lacrimal gland swelling or dacroadenitis
(3) sialadenitis
(4) proptosis
The diagnosis also involves excluding other explanations for the lesions.
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Specialty: Immunology/Rheumatology
