Description

Ettinger et al reviewed skin conditions associated with primary immunodeficiencies.

The authors are from University Medical Center Regensburg and University Hospital of Cologne.


Patient selection: primary immunodeficiency with nail changes

 

Nail changes:

(1) nail candidosis

(2) nail dystrophy

(3) dysplastic nails

 

Conditions associated with nail candidosis:

(1) APECED syndrome (AIRE)

(2) autosomal dominant hyper-IgE syndrome (HIES, Hiob/Job's syndrome (STAT3)

(3) dectin-1 deficiency (dectin-1)

 

Conditions associated with nail dystrophy:

(1) APECED syndrome (AIRE)

(2) dyskeratosis congenita (ACD, CTC1, DKC1)

(3) palmar and plantar hyperhidrosis, palmar hyperkeratosis (NHP2, RTEL1, NOP10, PARN, TCAB1, TERC/T, TINF2)

 

Conditions associated with dysplastic nails:

(1) autosomal recessive dyskeratosis congenita (NHP2/NOP10)


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