Nabi et al reported the SIP CHE score for identifying a patient with covert hepatic encephalopathy. The authors are from Virginia Commonwealth University and McGuire VA Medical Center in Richmond, Virginia.
SIP = Sickness Illness Profile (136 questions on 12 QOL topics)
CHE = covert hepatic encephalopathy
Parameters:
(1) age in years
(2) sex
(3) "I do not maintain balance" (SIP item BCM4)
(4) "I act irritable or impatient with myself" (SIP item EB7)
(5) "I am not doing any of my usual physical recreation or activities" (SIP item RP8)
(6) "I am eating much less than usual" (SIP item E1)
Parameter
Finding
Points
Beta-Coefficient
age in years
0.1 * (age)
0.0879 * (age)
sex
female
0
0
male
0.9
0.9151
balance not maintained
no
0
0
yes
2.6
2.6322
irritable or impatient
no
0
0
yes
2.4
2.4295
physical activities stopped
no
0
0
yes
1.9
1.8688
eating much less
no
0
0
yes
1.9
1.8870
SIP CHE score =
= SUM(points for all 6 parameters) - 6
value of X =
= SUM(all beta-coefficients) - 6.0016
probability of CHE =
= 1 / (1 + EXP((-1) * X))
Interpretation:
• A CHE score >= 0 is associated with covert hepatic encephalopathy.
Performance:
• The area under the ROC curve is 0.87.
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