Stephens et al developed simple risk scores for patients with chronic lymphocytic leukemia with del(17p13.1). These can help to identify a patient who may benefit from more aggressive management. The authors are from the University of Utah, the Ohio State University, University of Texas M.D. Anderson Cancer Center, and Peter MacCallum Cancer Centre in East Melbourne.
Patient selection: CLL with del(17p13.1)
Outcomes: treatment-free survival
Parameters:
(1) ECOG from 0 to 4
(2) Rai Stage from 0 to 4
(3) age in years
(4) WBC count in 10^9/L
(5) del(11q22.3)
Parameter
Finding
Points
ECOG
0
0
1
1
2 to 4
2
Rai Stage
0
0
1 to 4
2
age in years
< 65 years
0
>= 65 years
1
WBC count
< 50 * 10^9/L
0
>= 50 * 10^9/L
1
del(11q22.3)
no
0
yes
1
total score for treatment-free survival =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 7
• The higher the score the worse the treatment-free survival.
Score
2-Year Treatment-Free Survival
0 or 1
85%
2 or 3
51%
4
0%
Performance:
• The area under the ROC curve for treatment-free survival was 0.84.
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