Stephens et al developed simple risk scores for patients with chronic lymphocytic leukemia with del(17p13.1). These can help to identify a patient who may benefit from more aggressive management. The authors are from the University of Utah, the Ohio State University, University of Texas M.D. Anderson Cancer Center, and Peter MacCallum Cancer Centre in East Melbourne.
Patient selection: CLL with del(17p13.1)
Outcomes: overall survival
Parameters:
(1) ECOG from 0 to 4
(2) age in years
(3) serum LDH in IU/L
Parameter
Finding
Points
ECOG
0
0
1
1
2 to 4
2
age in years
< 65 years
0
>= 65 years
1
LDH
less than 2 times ULN
0
>= 2 times ULN
1
total score for overall survival =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 4
• The higher the score the worse the overall survival.
Score
2-Year Overall Survival
0
89%
2
66%
4
0%
Performance:
• The area under the ROC curve for overall survival was 0.73.
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