The erythrocyte sedimentation rate (ESR) is affected by the patient's hemoglobin and hematocrit levels as well as other factors (see previous section). Pawlotsky et al developed the Sigma ESR which involves adjusting the specimen hematocrit and summing readings taken at 4 times during the first hour of sedimentation. Pawlotsky has since developed a simplified version to increase acceptance of the approach.

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