Charles-Herve et al reported a simplified version of the Sequential/Sepsis Organ Failure Assessment (SOFA) score called the sa-SOFA. The authors are from multiple institutions in France.
Patient selection: adults in the intensive care unit (ICU)
Outcome: 28-day mortality
Parameters:
(1) PaO2 (in mm Hg) to FIO2 ratio as measure of respiratory function
(2) platelet count as a measure of coagulation
(3) serum total bilirubin in µmol/L as a measure of hepatic function
(4) total catecholamine dose in µg/kg/min as measure of cardiovascular function (over the first 24 hours in the ICU; norepinephrine+epinephrine+dobutamine)
(5) Glasgow coma scale as a measure of neurologic function
(6) urine output in mL per day as a measure of renal function
|
Parameter
|
Finding
|
Points
|
|
PaO2 to FIO2 ratio
|
>= 125
|
0
|
|
|
50 to 125
|
1
|
|
|
< 50
|
2
|
|
platelet count
|
>= 100,000 per µL
|
0
|
|
|
25,000 to 100,000
|
1
|
|
|
< 25,000 per µL
|
2
|
|
serum total bilirubin
|
< 75 µmol/L
|
0
|
|
|
75 to 299 µmol/L
|
1
|
|
|
>= 300 µmol/L
|
2
|
|
total catecholamine dose
|
< 0.75 µg/kg/min
|
0
|
|
|
0.75 to 1.99
|
1
|
|
|
>= 2.00 µg/kg/min
|
2
|
|
Glasgow coma scale
|
15
|
0
|
|
|
4 to 14
|
1
|
|
|
3
|
2
|
|
urine output
|
>= 2000 mL per day
|
0
|
|
|
500 to 2000 mL per day
|
1
|
|
|
< 500 mL per day
|
2
|
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 12
• The higher the score the greater the mortality rate.
Performance:
• The area under the ROC curve is 0.74.
