Handler et al reported several signals that can help to detect an adverse drug reaction in a nursing home resident. One signal involves the use of antidotes. The authors are from Veterans Affairs Pittsburgh Healthcare System and the University of Pittsburgh.
Patient selection: nursing home resident
Antidote
And the Patient Is Receiving
naloxone
opioid analgesic
phytonadione (vitamin K)
warfarin
dextrose 50%, glucogon, liquid glucose
drug that can cause hypoglycemia
protamine sulfate
unfractionated heparin
digoxin immune Fab
digoxin
epinephrine
drug capable of causing anaphylaxis
oral metronidazole or oral vancomycin
drug capable of causing pseudo-membranous enterocolitis (C. difficile disease)
benztropine, diphenhydramine or trihexyphenidyl
drug capable of causing extrapyramidal symptoms
lepirudin
heparin
sodium polystyrene
drug capable of causing hyperkalemia
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