This is a screening tool for differentiating heterozygous beta-thalassemia from healthy subjects. It cannot discriminate between beta-thalassemia and iron deficiency.
Shine-Lal formula =
= (((MCV)^2) * (MCH)) / 100
where:
• MCV is the mean corpuscular volume as measured in femtoliters
• MCH is the mean corpuscular hemoglobin as measured in picograms
Interpretation:
• thalassemia minor: < 1530.
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