Antzelevitchet al proposed the Shanghai Score for the diagnosis of Brugada Syndrome (BrS).
Parameters:
(1) 12-lead ambulatory ECG
(2) clinical history
(3) family history
(4) genetic test result
|
Clinical Finding |
Points |
|
unexplained cardiac arrest |
3 |
|
documented VF or polymorphic VT |
3 |
|
nocturnal agonal respirations |
2 |
|
suspected arrhythmic syncope |
2 |
|
syncope of unclear etiology or mechanism |
1 |
|
atrial flutter or fibrillation in a patient < 30 years old without alternative etiology |
0.5 |
|
none of the above |
0 |
subscore for clinical findings =
= MAX(points for clinical findings)
|
Parameter |
Finding |
Points |
|
12-lead ambulatory ECG |
spontaneous type 1 Brugada pattern at nominal or high leads |
3.5 |
|
|
fever-induced type 1 Brugada pattern at nominal or high leads |
3 |
|
|
type 2 or 3 Brugada ECG pattern that converts with provocative drug challenge |
2 |
|
|
other |
0 |
|
family history |
definite BrS in first or second degree relative |
2 |
|
|
suspicious sudden cardiac death in first or second degree relative |
1 |
|
|
unexplained sudden cardiac death in first or second degree relative less than 45 years old |
0.5 |
|
|
other |
0 |
|
genetic test |
probable pathogenic mutation in BrS susceptibility gene |
0.5 |
|
|
other |
0 |
where:
• Suspicious sudden cardiac death is associated with fever, occurrence at night or with Brugadaaggravating drugs).
• Unexplained sudden cardiac death is associated with a negative autopsy.
total score =
= SUM(subscore for clinical findings, points for other parameters)
Interpretation:
• minimum score: 0
• maximum score: 9
|
Score |
Brugada Syndrome (BrS) |
|
>= 3.5 |
probable or definite BrS |
|
2 to 3 |
possible BrS |
|
< 2 |
nondiagnostic of BrS |
Specialty: Cardiology
