Barosi et al developed a severity score for evaluating patients with myelofibrosis and myeloid metaplasia. The authors are from multiple institutions in Italy and France.
Components of the Severity Score:
(1) myelodepletive index
(2) myeloproliferative index
Parameters for the myelodepletive index:
(1) anemia (hemoglobin)
(2) leukopenia (white blood cell count)
(3) thrombocytopenia (platelet count)
|
Parameter |
Finding |
Points |
|
hemoglobin |
>= 12 g/dL |
0 |
|
|
10 - 11.99 g/dL |
1 |
|
|
< 10 g/dL |
2 |
|
white blood cell count |
>= 4,000 per µL |
0 |
|
|
< 4,000 per µL |
1 |
|
platelet count |
> 150,000 per µL |
0 |
|
|
<= 150,000 per µL |
1 |
Parameters for the myeloproliferative index:
(1) splenomegaly
(2) leukocytosis (white blood cell count)
(3) thrombocytosis (platelet count)
|
Parameter |
Finding |
Points |
|
splenomegaly |
nonpalpable |
0 |
|
|
removed |
0 |
|
|
palpable <= 10 cm below costal margin |
1 |
|
|
palpable > 10 cm below costal margin |
2 |
|
white blood cell count |
< 15,000 per µL |
0 |
|
|
>= 15,000 per µL |
1 |
|
platelet count |
< 500,000 per µL |
0 |
|
|
>= 500,000 per µL |
1 |
myelodepletive index =
= SUM(points for all 3 parameters)
myeloproliferative index =
= SUM(points for all 3 parameters)
severity score =
= (myelodepletive index) + (myeloproliferative index)
Interpretation:
• minimum index score: 0
• maximum index score: 4
• minimum severity score: 0
• maximum severity score: 6 (there is overlap in WBC and platelet counts in each index)
• The higher the severity score, the more severe the disease.
Specialty: Hematology Oncology
ICD-10: ,
