Perazzoli et al reported a score for evaluating a patient with febrile neutropenia and colorectal disease. This can help to identify a patient who may require more aggressive management. The authors are from the University of Sao Paulo in Brazil.
Patient selection: febrile, absolute neutrophil count <= 1,000 per µL, colorectal disease
Parameters:
(1) underlying disease
(2) absolute neutrophil count per microliter
(3) duration of neutropenia in days
(4) current therapeutic modality
(5) colorectal disorder
Parameter
Finding
Points
underlying disease
multiple myeloma, ES, EM
1
low or intermediate grade NHL, Hodgkin's, CLL
2
AA, MDS, accelerated phase CML
3
AML, ALL, high-grade NHL, blastic phase CML
4
absolute neutrophil count
501 to 1,000 per µL
101 to 500 per µL
<= 100 per µL
duration of neutropenia
<= 7 days
8 to 14 days
>= 15 days
current therapeutic modality
autologous HSCT, other
combination chemotherapy
allogenic HSCT
colorectal disorder
nonseptic anorectal focus
septic anorectal focus
intra-abdominal focus
where:
• The abbreviations used for underlying disease were not explained.
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 5
• maximum score: 16
Total Score
Risk Group
Mortality (Absolute Risk)
5 to 8
I
0%
9 to 12
II
6.2%
13 to 16
III
40%
Performance:
• The area under the ROC curve is reported as 0.88.
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Specialty: Infectious Diseases
