A serum sickness-like reaction resembles a true serum sickness reaction but lacks several features.
History: exposure to a drug 1 to 3 weeks prior to onset of clinical features
Clinical features of a serum sickness-like reaction:
(1) fever
(2) pruritis
(3) urticaria and/or skin rash
(4) polyarthralagia
Features of true serum sickness that are absent:
(1) circulating immune complexes
(2) hypocomplementemia
(3) vasculitis
(4) renal lesions
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Purpose: To evaluate a patient for findings of a serum sickness-like reaction.
Specialty: Immunology/Rheumatology
Objective: differential diagnosis and mimics, red flags
ICD-10: T80.6,
