Serum Lactate Dehydrogenase (LDH) to Absolute Lymphocyte Count Ratio

Background: The serum LDH may correlate with tumor burden. The absolute lymphocyte can reflect malnutrition and/or an impaired immune response.

Parameters:

(1) serum LDH in U/L

(2) absolute lymphocyte count in 10^9/L

LDH to lymphocyte ratio =

= (serum LDH) / (absolute lymphocyte count)

Interpretation:

• The cutoff for the ratio that identifies a high risk group varies with the tumor.

• A ratio > 400 is associated with poor survival in diffuse large B-cell lymphoma.

• A ratio >= 150 is associated with poor overall survival in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors.

• A ratio > 168.8 is associated with worse survival for a patient with primary CNS lymphoma.